Celecoxib significantly reduces opioid use after shoulder arthroplasty

Background The opioid crisis has illuminated the risks of use for pain management, with renewed interest in reducing consumption after common orthopedic procedures. Anti-inflammatory medication is an important component multimodal management patients undergoing surgery. purpose this study was to evaluate effect celecoxib on control and shoulder Methods Patients scheduled either total replacement (group 1) or rotator cuff repair 2) were candidates study. exclusion criteria included allergy celecoxib, coagulopathy, anticoagulants, baseline long-acting opioids, a history medical conditions such as myocardial infarction stroke. Consenting randomized by type procedure using block randomization receive placebo 1 hour prior 3 weeks postoperatively. primary outcome measure assessed utilization measured morphine-equivalent dose (MED). Secondary measures scores at 6 Data analyzed multiple linear regression. Results Of 1081 from February 2014 2018, 78 enrolled arthroplasty 1, 39 receiving placebo) 79 2, 40 placebo). Compared arm, prescribed took fewer MEDs –168 (95% confidence interval [CI], –272 –64; P < .01) population –197.7 CI, –358 –38; = .02) group. Similarly, weeks, used –199 –356 –42; –270 –524 –16; .04) No statistically significant differences found between arms group, weeks. note, preoperative associated higher levels group (P .01 all) but not 2 > .05 both). Conclusions Use morphine equivalents significantly less who surgery Multimodal effective way reduce postoperative patients. Preoperative arthroplasty.